Tumour development occurs to a large extent because of dysregulation of the cell cycle. Of particular importance are defects occurring in the G1 phase. The reason why G1 is critical is because of the influence of several signals (external signals as well as cyclins and cdks) on this stage. The G1 phase can be divided into two parts, G1pm and G1ps. Each part has its ?own? restriction point which needs to be passed in order to progress to S phase.

Many IT projects that have been developed in recent years are often considered to be unsuccessful. According to a study by Exido up to the 72% of all IT projects are considered to be failed. A failed IT projects means that the organizations that have ordered the new system may have higher costs or/and the system will not be ready in time. If costs are too high the new system might not be installed in the organization or if the system is not completed within the specified time frame the organization can become stagnant.In this paper we conduct an investigation of the failure of IT projects there we will examine where, in the systems development lifecycle four different phases, projects fail. We will conduct an empirical study of each phase, where we describe the key steps in the process; we will also investigate failed IT projects that are linked to the current phase.

In a society where adults set the conditions for children?s play and generate modern and at times technically advanced products, fundamental characteristics like simplicity, opportunities for motor skills training and learning tend to be neglected. Owing to this, the Linköping-based company Time In wants to introduce a new multifunctional product, which differs from other products in shape and function and lives up to the often overlooked, basic characteristics in a toy.With Time In as the assigner, the purpose of this master thesis has been to use simple means to produce a "learning by playing" concept. Since Time In sells toys and products suitable for children in nurseries and preschools, the development of the products has therefore included a study of nursery and preschool environments.The thesis has been carried out within the Product Design subject area at the Department of Management and Engineering at Linköping University. Concept development has been done in three phases: the Preparation phase, the Design phase and the Presentation phase.

Many IT projects that have been developed in recent years are often considered to be unsuccessful. According to a study by Exido up to the 72% of all IT projects are considered to be failed. A failed IT projects means that the organizations that have ordered the new system may have higher costs or/and the system will not be ready in time. If costs are too high the new system might not be installed in the organization or if the system is not completed within the specified time frame the organization can become stagnant.In this paper we conduct an investigation of the failure of IT projects there we will examine where, in the systems development lifecycle four different phases, projects fail. We will conduct an empirical study of each phase, where we describe the key steps in the process; we will also investigate failed IT projects that are linked to the current phase.

The purpose of this paper was to investigate the special services for immigrants which are offered by Swedish libraries on their different levels regional, local and school as well as immigrants experiences of the library services and how these services and experiences conduct themselves to the development of the harmonic multicultural society. The methods used were interpreting reflexive interviews with immigrants and librarians. The guiding theory in this study was a three-phase model by Gillis Herlitz according to which a newcomer goes through three stages in an adaptation period. Phase 1 is a positive honeymoon phase, that later is replaced by phase 2, a critical disappointment period, which then ideally should be resolved in phase 3, where the individual reaches a balancing stage of cultural adaptation. The results of my observations indicate that the performances of the different libraries seem to operate in a way that corresponds to the different phases in this model.

I denna uppsats behandlas de grammatiska fenomenen complete phase och incomplete phase i det austronesiska språket rotumanska. Min avsikt med uppsatsen är att ta reda på varför complete phase respektive incomplete phase används i en viss syntaktisk eller morfologisk kontext. Jag har baserat denna studie endast på litteratur, främst från C.M Churchwards Rotuman Grammar and Dictionary..

The aim of this study was to investigate the intraoperative surgical stress response in dogs undergoing ovariohysterectomy and to compare acepromazine and medetomidine as premedications. 15 dogs diagnosed with pyometra were used in this study. Blood pressure and heart rate were used as parameters to measure surgical stress response. The surgery was divided into four phases. Phase 0 was the period 10 minutes before the skin incision, phase 1 was skin incision and opening of abdomen, phase 2 was manipulation of uterine horns, ligation and transection of mesovarium and phase 3 was ligation of cervix, removal of organs and closing the abdomen. The results showed that phase 2 was the most intense phase of surgical stress, regardless of which premedication the dogs received. When acepromazine and medetomidine were compared the results showed that within phase 3, all dogs that were given medetomidine had higher blood pressure compared to dogs that were given acepromazine. The dogs that were given acepromazine had higher heart rate than the dogs that were given medetomidine in phase 0, phase 2 and phase 3. .

This degree project concludes the Innovation and Design Engineering programme at Karlstad University. The project was carried out by David Brocker, Erik Hallberg and Andreas Hertzman during the spring of 2006 and corresponded to 15 weeks of work per student. Assigner was Martin Larsson at Arexor and instructor at Karlstad University was Monica Jakobsson.Arexor has a patent to a construction of an electrical skirting board with moveable wall sockets, called Electrical Track System. The lowest parts of the interior walls along the floor are today almost always covered by a conventional skirting board. Arexors patented product replaces that with the possibility to move and increase the number of wall sockets by choice along an electrical skirting board.

This report is a documentation of a Master?s thesis of 20 credits performed at the educational program of Technical Product- and Production Development with Design at Halmstad University. The project is carried out in cooperation with Hafa AB in Halmstad.The purpose of this project was to bring forth a concept of a bathroom cabinet for Hafa?s new selection Young through creative design methods. The selection is supposed to attract the younger purchaser but also a target group that dare to experiment with home furnishing and appreciates new design.

In the pulp industry, digesters are used to disolve lignin in wood chips. The concentration of lignin is measured and is called the Kappa number. In this thesis, the question of whether an online Kappa sensor, taking samples from the mid-phase of the digester, is useful or not is analyzed. For the samples to be useful, there has to be a relationship between the measured Kappa at the mid- phase and the measured Kappa in the blowpipe at the bottom of the digester. An ARX model of the lower part of the digester has been estimated.

The cell cycle is the time a cell spends between two cell divisions. The cell cycle includes several parallel processes, all of which must be completed before a cell is mature for dividing. In the first place, all subcomponents (RNA, protein and membrane lipids) need to double in quantity and this occurs continuously through the cell cycle. Furthermore, the genome and some chromosomal proteins must double and this take place during a limited interval in the middle of the cell cycle (S-phase). On either side of the S-phase are two "gaps" which is called G1 and G2. When the cell has passed a point in the G-phase they are irreversibly programmed to progress through the remaining of the cell cycle and will undergo the next cell division. When a cell have passed a point in the G1 phase, approximately four hours after mitosis, a normal cell is in a state of indecision.

The project is about making a Re-Design of the Swedish Socialistic Newspaper ?Dagens ETC?. The background to the project is my search for commitment when I work with a specific customer or project and how importantthat commitment are?The project was from the beginning split up to three different phases. The meaning of the first phase where to make a re-design mainly based on a interview with Johan Ehernberg, the chef editor on ETC.The second phase was a design totally made of my own idea and creative view as a Graphic Designer.I had in mind to make the third phase based on the result of the first two phases.During phase one and two I reconsidered and decided to skip the third step and put more effort in to the two first ones.

The process of producing a video game is one that goes through a number of phasesduring the span of the entire production. One of these phases is the concept design phase,which is part of the pre-production. This phase is an important aspect of the productionas it is where all the different parts and ideas concerning the game are brought togetherto define what the game is going to be. Though a clearly important part of the videogame production surprisingly little research have been done on the subject of conceptdesign. This thesis presents what place concept design has in the overall game productionand how the design process is handled.

The development of IT systems is usually accomplished by some form of system development methodology. It can be performed as the waterfall method, where each phase is completed before the next begins. One of the reasons to follow a development methodology is that the process is more structured, faster and that the product will have higher quality. One risk of not using a system development approach is that the code can be unstructured and difficult to maintain.This paper describes an alternative method in which the development occurred without the use of any system development methodology. This has been possible because there was a clear goal of the program that should be developed.

This thesis report describes the development of concepts regarding how weight can be reduced to the analytical instrument Biacore 4000. This thesis has resulted in five different concept proposals, all of which is solutions to reduce the instrument's weight.The thesis started with a pre-study where the instrument's structure and function were studied using both Solid Works, the opportunity to study the instrument in real life were also possible done. During this phase, a weight study was conducted as well, in which the instrument's weight distribution was studied and mapped.Following the initial phase, the work proceeded by developing concrete concepts to reduce the weight of the instrument where focus mainly was on the two cabinets. In addition, another two concepts were revealed, both with a more general approach.At the final phase of the thesis, the concepts were compiled and evaluated among themselves and the initial instrument.The thesis resulted in a study of the instrument's structure and weight distribution, with suggestions on how weight may be reduced for the instrument.The result factors such as materials, and manufacturing were aspects that were taken into consideration.At the final section of the report, suggestions for further work in which different aspects are discussed can be found..